Work

The protein phosphatase 2C (PP2C) superfamily: Detection of bacterial homologues

Year: 1996

Type: article

Abstract: A thorough sequence analysis of the various members of the eukaryotic protein serine/threonine phosphatase 2C (PP2C) family revealed the conservation of 11 motifs. These motifs could be identified in numerous other sequences, including fungal adenylate cyclases that are predicted to contain a functionally active PP2C domain, and a family of prokaryotic serine/threonine phosphatases including SpoIIE. Phylogenetic analysis of all the proteins indicates a widespread sequence family for which a considerable number of isoenzymes can be inferred.

Source: Protein Science

DOI: 10.1002/pro.5560050720

Authors: Peer Bork, Nigel P. Brown, Hedvig Hegyi, Jörg Schultz

Institutions: European Molecular Biology Laboratory, Max Delbrück Center

Language: English

Topic: Protein Tyrosine Phosphatases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2027894194

FWCI: 3.271

Cites: 33

Cited by: 203

Related to: 10