Year: 1994
Type: article
Abstract: Adults with GH-deficiency have increased mortality due to cardiovascular disease and share several clinical signs, such as reduced muscle strength, reduced exercise capacity, reduced sweating ability and thermoregulation, subnormal kidney function, reduced myocardial function, reduced energy expenditure, abnormal thyroid hormone metabolism, impaired psychosocial well-being, decreasing lean body mass and decreased bone mineral content. All studies have unanimously shown that GH replacement therapy in GH-deficient adults have improved all the above reported clinical symptoms.We conclude that GH-deficiency in adults is associated with a number of subnormal features. GH treatment improves (normalizes) these symptoms and we therefore believe that GH replacement therapy of a GH-deficient individual should be continued after cessation of linear growth. However, treatment of such patients should be carefully monitored since data from follow-up studies are still lacking.
Source: Clinical Pediatric Endocrinology
Institutions: University of Copenhagen, Aarhus University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2027983605