Work

Photobiological implications of melanin photoprotection after UVB ‐induced tanning of human skin but not UVA ‐induced tanning

Year: 2014

Type: article

Abstract: Repetitive suberythemal UVA and/or UVB exposures were used to generate comparable UV-induced tans in human skin over the course of 2 weeks. To evaluate the potential photoprotective values of those UVA- and/or UVB- induced tans and to avoid the confounding issue of residual UV-induced DNA damage, we waited 1 week before challenging those areas with a 1.5 MED of UVA+UVB after which we measure DNA damage. The results show that the type of UV used to induce skin pigmentation affects the redistribution of melanin in the skin and/or de novo melanin synthesis. The UVA-induced tans failed to even provide a minimal SPF of 1.5, which suggests that producing a tan with UVA-rich sunlamps prior to a holiday or vacation is completely counterproductive.

Source: Pigment Cell & Melanoma Research

DOI: 10.1111/pcmr.12331

Authors: Sergio G. Coelho, Lanlan Yin, Christoph Smuda, Andre Mahns, Ludger Kolbe, Vincent J. Hearing

Institutions: National Institutes of Health, National Cancer Institute, Beiersdorf (Germany)

Language: English

Topic: Skin Protection and Aging

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute