Work

Copper-Catalyzed Arylation of Heterocycle C−H Bonds

Year: 2007

Type: article

Abstract: A new method for the direct, copper-catalyzed arylation of heterocycle C−H bonds by aryl halides has been developed. In addition to electron-rich five-membered heterocycles, electron-poor pyridine oxides can also be arylated. The best results are obtained by using a combination of lithium tert -butoxide base, aryl iodide coupling partner, and copper iodide catalyst.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja075802+

Authors: Hien-Quang Do, Olafs Daugulis

Institution: University of Houston

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: New Methods for Direct Carbon-Hydrogen Bond Functionalization