Association of Polymorphisms in Neuroprotection and Oxidative Stress Genes and Neurodevelopmental Outcomes After Preterm Birth
Year: 2012
Type: article
Abstract: OBJECTIVE: To estimate the associations between polymorphisms in neuronal homeostasis, neuroprotection, and oxidative stress candidate genes and neurodevelopmental disability. METHODS: This was a nested case-control analysis of a randomized trial of magnesium sulfate administered to women at imminent risk for early (before 32 weeks) preterm birth for the prevention of death or cerebral palsy in their offspring. We evaluated 21 single-nucleotide polymorphisms (SNPs) in 17 genes associated with neuronal homeostasis, neuroprotection, or oxidative stress in umbilical cord blood. Cases included infant deaths (n=43) and children with cerebral palsy (n=24), mental delay (Bayley Mental Developmental Index less than 70; n=109), or psychomotor delay (Bayley Psychomotor Developmental Index less than 70; n=91) diagnosed. Controls were race-matched and sex-matched children with normal neurodevelopment. Associations between each SNP and each outcome were assessed in logistic regression models assuming an additive genetic pattern, conditional on maternal race and infant sex, and adjusting for study drug assignment, gestational age at birth, and maternal education. RESULTS: The odds of cerebral palsy were increased more than 2.5 times for each copy of the minor allele of vasoactive intestinal polypeptipe (VIP, rs17083008) (adjusted odds ratio 2.67, 95% confidence interval 1.09-6.55, P=.03) and 4.5 times for each copy of the minor allele of N-methyl-D-aspartate receptor subunit 3A (GRIN3A, rs3739722) (adjusted odds ratio 4.67, 95% CI 1.36-16.01, P=.01). The association between the advanced glycosylation end product-specific receptor (AGER, rs3134945) SNP and mental delay was modulated by study drug allocation (P=.02). CONCLUSION: Vasoactive intestinal polypeptipe and GRIN3A SNPs may be associated with cerebral palsy at age 2 in children born preterm.
Source: Obstetrics and Gynecology
Institutions: The University of Texas Medical Branch at Galveston, University of North Carolina at Chapel Hill, National Institutes of Health, University of Pittsburgh, University of Utah, Brown University, University of Alabama at Birmingham, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Case Western Reserve University, University of Tennessee at Knoxville, Columbia University
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1092124974, G1216570417, General Clinical Research Center, G161141704, Maternal Fetal Medicine Network: Data Coordinating Cent*, G1873590977, G1882602020, Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network, Maternal Fetal Medicine Units Network, MULTICENTER NETWORK OF MATERNAL-FETAL MEDICINE UNITS, G2254024324, G2344880343, NICHD Maternal Fetal Medicine Units Network, G2594613454, NICHD Maternal-Fetal Medicine Units (MFMU) Network, Genetic Polymorphisms Associated with Cerebral Palsy and Neurodevelopmental Delay, G284963502, G2925552923, G29782494, Maternal-Fetal Medicine Units Network, G307553905, G3170774280, NICHD Maternal Fetal Medicine Units Network, G3218948901, G3305698765, G3579211174, G3681478966, Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network, Cooperative Multicenter Maternal Fetal Medicine Units Networks, G3786447104, G3875946430, G4027080872, G4189700973, Co-Operative Multicenter Trials in Obstetrics & Maternal Fetal Medicine, G4259014447, Data Coord Ctr-NICHD Cooperative Multicenter Maternal Medicine Units Research Net, MULTICENTER NETWORK OF MATERNAL-FETAL MEDICINE UNITS, MULTICENTER NETWORK OF MATERNAL-FETAL MEDICINE UNITS, Multicenter Network of Maternal Fetal Medicine Units, G4657398957, G4772972313, G5050941685, G50908112, G5273235862, Maternal Fetal Medicine Units Network, G5369184038, G5425254544, G5864221601, MULTICENTER NETWORK OF MATERNAL-FETAL MEDICINE UNITS, G5987270356, G6113204387, Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network (U10), G6657596466, G673807916, Brown/WIH Eunice Kennedy Shriver NICHD MFM Units Network Site, MULTICENTER NETWORK OF MATERNAL-FETAL MEDICINE UNITS, Maternal Fetal Medicine Network, G7372122175, G7674919133, G7685159543, NICHD NETWORKS: DATA COORDINATING CENTER, G7750490871, NICHD Materal Fetal Medicine Units Network, G8249635142, MULTICENTER NETWORK OF MATERNAL-FETAL MEDICINE UNITS, G8597359909, G8623653352, G8650048904, G8759751075, G8919699124, G9000034342, G9000075942, G9000086688, G9000090292, G9000121484, G9000139331, G9000158709, G9000207554, G9000212338, G9000228071, G9000241794, G9000265967, G9000270634, G9000317447, UofU Maternal-Fetal Medicine Units (MFMU) Network: Clinical Centers, NICHD Maternal-Fetal Medicine Units (MFMU) Network: Data CoordinatingCenter, Brown University/Women & Infants Hospital of Rhode Island (WIH) Center Application for the Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network, Maternal Fetal Medicine Units Network - Northwestern Study Center, Maternal-Fetal Medicine Units (MFMU) Network, Case Western Reserve University Center of the NICHD MFMU Network, Columbia University Maternal-Fetal Medicine Units Network Clinical Center, NICHD maternal fetal medicine units network, UNC MFMU: Advancing Perinatal Health via Definitive, Multi-Site Clinical Studies, Eunice Kennedy Shriver NICHD Maternal-Fetal Medicine Units (MFMU) Network (UG1), G922324195
OpenAlex ID: W2028384024