Work

Monocyclic .BETA.-lactam antibiotics: Synthesis and antibacterial activity of 4-(substituted ethyl)-2-azetidinone-1-sulfonic acid derivatives.

Year: 1987

Type: article

Abstract: The synthesis and antibacterial activity of sodium (3S,4R)-3-[2-(2-aminothiazol-4-yl)-(Z)-2-(O-substituted oxyimino)acetamido]-2-azetidinone-1-sulfonates having various substituted ethyl groups at the C-4 position are described. Among various substituents explored, the (substituted isothiuronio)ethyl groups were found to have strong antibacterial activity against a variety of Gram-negative bacteria, and moreover, the ethylene isothiuronium derivative exhibited moderate antibacterial activity against Staphylococcus aureus.

Source: The Journal of Antibiotics

DOI: 10.7164/antibiotics.40.1716

Authors: HARUO YAMASHITA, NOBUYOSHI MINAMI, KYOICHI SAKAKIBARA, SUSUMU KOBAYASHI, MASAJI OHNO, MASA HAMADA, HAMAO UMEZAWA

Institution: The University of Tokyo

Language: English

Topic: Synthesis of β-Lactam Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2028436326

FWCI: 0.54

Cites: 8

Cited by: 9

Related to: 10