Work

Effect of Topical Retinoic Acids on the Levels of Collagen mRNA During the Repair of UVB-Induced Dermal Damage in the Hairless Mouse and the Possible Role of TGF-β as a Mediator

Year: 1992

Type: article

Abstract: Topically applied retinoic acids have been found to enhance the gene expression for collagen types I and III in the skin of UVB-irradiated hairless mice. Prior damage is required because the effect is not observed in the skin of age-matched, non-irradiated control animals. Immunochemical methods have shown an increase in TGF-beta 1 and, to a lesser extent, of TGF-beta 2 in the epidermis following retinoic acid treatment. There were no changes in mRNA levels for any of the isotypes of TGF-beta induced by retinoic acid treatment. This study suggests that TGF-beta may mediate the effect of retinoic acids on dermal repair through the stimulation of collagen gene expression.

Source: Journal of Investigative Dermatology

DOI: 10.1111/1523-1747.ep12499805

Authors: Hee-Joong Kim, Nancy J Bogdan, Lillian J D'Agostaro, Leslie I Gold, Graeme F Bryce

Institutions: NYU Langone Health, New York University

Language: English

Topic: Skin Protection and Aging

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,800