Work

A20: Central Gatekeeper in Inflammation and Immunity

Year: 2008

Type: review

Abstract: Inappropriate functioning of the immune system is linked to immune deficiency, autoimmune disease, and cancer. It is therefore not surprising that intracellular immune signaling pathways are tightly controlled. One of the best studied transcription factors in immune signaling is NF-kappaB, which is activated by multiple receptors and regulates the expression of a wide variety of proteins that control innate and adaptive immunity. A20 is an early NF-kappaB-responsive gene that encodes a ubiquitin-editing protein that is involved in the negative feedback regulation of NF-kappaB signaling. Here, we discuss the mechanism of action of A20 and its role in the regulation of inflammation and immunity.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.r800032200

Authors: Beatrice Coornaert, Isabelle Carpentier, Rudi Beyaert

Institutions: Ghent University, Vlaams Instituut voor Biotechnologie, VIB-UGent Center for Inflammation Research

Language: English

Topic: NF-κB Signaling Pathways

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430