Work

No association of the serotonin transporter polymorphisms 5‐HTTLPR and RS25531 with schizophrenia or neurocognition

Year: 2010

Type: article

Abstract: A promoter polymorphism in the serotonin transporter gene has been widely studied in neuropsychiatry. We genotyped the 5-HTTLPR/rs25531 triallelic polymorphism in 728 schizophrenia cases from the CATIE study and 724 control subjects. In a logistic regression with case/control status as dependent variable and 7 ancestry-informative principal components as covariates, the effect of 5-HTTLPR/rs25531 composite genotype was not significant (odds ratio = 1.008, 95% CI 0.868-1.172, P = 0.91). In cases only, 5-HTTLPR/rs25531 was not associated with neurocognition (summary neurocognitive index P = 0.21, working memory P = 0.32) or symptomatology (PANSS positive P = 0.67 and negative symptoms P = 0.46). We were unable to identify association of the triallelic 5-HTTLPR with schizophrenia, neurocognition, or core psychotic symptoms even at levels of significance unadjusted for multiple comparisons.

Source: American Journal of Medical Genetics Part B Neuropsychiatric Genetics

DOI: 10.1002/ajmg.b.31077

Authors: Thomas I. Konneker, James J. Crowley, Corey R. Quackenbush, Richard S.E. Keefe, Diana O. Perkins, T. Scott Stroup, Jeffrey A. Lieberman, Edwin van den Oord, Patrick F. Sullivan

Institutions: University of North Carolina at Chapel Hill, Duke University, Columbia University, Virginia Commonwealth University, Karolinska Institutet

Language: English

Topic: Schizophrenia research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: University of Pennsylvania, Emory University, Northwestern University, Louisiana State University, National Institutes of Health, School of Medicine, Emory University, National Institute of Mental Health

Awards: G1121004391, 1/2 A Large-Scale Schizophrenia Association Study in Sweden, Molecular Genetics of Schizophrenia, Molecular Genetics of Schizophrenia, G4096236044, Molecular Genetics of Schizophrenia, Molecular Genetics of Schizophrenia, G445903376, Molecular Genetics of Schizophrenia, Molecular Genetics of Schizophrenia, Molecular Genetics of Schizophrenia, Molecular Genetics of Schizophrenia, Molecular Genetics of Schizophrenia, Replication of Schizophrenia Associations in CATIE, G8163728846, CLINICAL ANTIPSYCHOTIC TRIALS OF INTERVENTION EFFECTIVES, Molecular Genetics of Schizophrenia, G8700482840

OpenAlex ID: W2029064052

FWCI: 1.527

Cites: 10

Cited by: 17

Related to: 10