Work

Comparative Histomorphological Review of Rat and Human Hepatocellular Proliferative Lesions

Year: 2012

Type: article

Abstract: In this comparative review, histomorphological features of common nonneoplastic and neoplastic hepatocyte lesions of rats and humans are examined using H&E-stained slides. The morphological similarities and differences of both neoplastic (hepatocellular carcinoma and hepatocellular adenoma) and presumptive preneoplastic lesions (large and small cell change in humans and foci of cellular alteration in rats) are presented and discussed. There are major similarities in the diagnostic features, growth patterns and behavior of both rat and human hepatocellular proliferative lesions and in the process of hepatocarcinogenesis. Further study of presumptive preneoplastic lesions in humans and rats should help to further define their role in progression to hepatocellular neoplasia in both species.

Source: Journal of Toxicologic Pathology

DOI: 10.1293/tox.25.189

Authors: Bob Thoolen, Fiebo J.W. ten Kate, Paul J. van Diest, David E. Malarkey, Susan A. Elmore, Robert R. Maronpot

Institutions: University Medical Center Utrecht, National Institute of Environmental Health Sciences

Language: English

Topic: Liver physiology and pathology

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2029290010

FWCI: 1.42

Cites: 93

Cited by: 44

Related to: 10