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Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia

Year: 2013
Type: article
Study design: Observational Study
Abstract: BACKGROUND: A hormonal aetiology is one explanation for the lower incidence of myeloid leukaemia in women compared with men. METHODS: In this population-based case-control study, we evaluated associations between exogenous hormone use and reproductive history and myeloid leukaemia, overall and by disease subtype. RESULTS: We observed a suggestive association between oral contraceptive use and acute myeloid leukaemia (odds ratio=0.55, 95% confidence interval=0.32-0.96). Hormone replacement therapy and reproductive factors were not associated with risk. CONCLUSION: Despite the biological plausibility for a role of oestrogen in leukaemogenesis, other aetiologic factors are likely to explain the differing incidence rates in males and females.
DOI: 10.1038/bjc.2013.507
Authors: J N Poynter, R Fonstad, C K Blair, M Roesler, J R Cerhan, B Hirsch, P Nguyen, J A Ross
Language: English
Subfield: Hematology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $5,190
Awards: G1136895392, G1846376946, Predictors of Adult Leukemia, G5520316217, G9000180435, G9000185412, G9000257145
OpenAlex ID: W2029328137
FWCI: 0.64
Cites: 20
Cited by: 9
Related to: 20