Work

Open-label pilot study of bupropion plus bromocriptine for treatment of cocaine dependence

Year: 2002

Type: article

Abstract: Combinations of medications are often used in neuropsychiatry to enhance treatment efficacy. This 8-week, open-label study tested the combination of bupropion (< or =300 mg) and bromocriptine (< or =7.5 mg) daily in 34 cocaine-dependent (DSM-IIIR) outpatients also receiving weekly individual counseling. The first 18 subjects spent one week at maximum dose; the next 16 spent three weeks. Both groups showed significant reductions in self-reported cocaine use, with no significant change in proportion of urine toxicology tests positive for cocaine. There were no significant differences in outcome between groups. These results suggest that the combination of bupropion and bromocriptine is safe in cocaine addicts, but provide ambiguous evidence of its efficacy.

Source: The American Journal of Drug and Alcohol Abuse

DOI: 10.1081/ada-120001288

Authors: Ivan D. Montoya, Kenzie L. Preston, Richard Rothman, David A. Gorelick

Institutions: National Institutes of Health, National Institute on Drug Abuse

Language: English

Topic: Substance Abuse Treatment and Outcomes

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Drug Abuse