Work

Garrotes, Springs, Ratchets, and Whips: Putting Dynamin Models to the Test

Year: 2000

Type: review

Abstract: The GTPase dynamin is essential for clathrin-mediated endocytosis. Numerous new and exciting discoveries regarding dynamin function in vivo and in vitro have led to various models in which dynamin functions directly in membrane fission and the release of clathrin-coated vesicles from the plasma membrane. This would make dynamin unique among GTPases in its ability to act as a mechanochemical enzyme. Here we review the various models and their supporting data. We then discuss new findings that raise doubts as to whether dynamin breaks the paradigm that governs regulatory GTPases.

Source: Traffic

DOI: 10.1034/j.1600-0854.2000.010503.x

Authors: Sanja Sever, Hanna Damke, Sandra L. Schmid

Institutions: Harvard University, Dana-Farber Cancer Institute, Scripps Research Institute

Language: English

Topic: Cellular transport and secretion

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: Thailand Science Research and Innovation, National Institutes of Health, National Institute of General Medical Sciences

Award: Dynamin-1: a nexus for reciprocal regulation of endocytosis and signaling