Work

N-6 substituted deoxygenated derivatives of L-like 5'-noraristeromycin

Year: 2010

Type: article

Abstract: Several N-6 substituted derivatives (4-11) of (+)-4'-deoxy-5'-noraristeromycin (2) and its unsaturated counterpart (3) have been prepared. The derivatives are designed to systematically vary the hydrophobic/hydrophilic balance of the lead compounds. These compounds were evaluated against a large number of viruses but no significant antiviral activity was observed. Also, no cytotoxicity to host cells was found. KEY WORDS: L-like, Carbocyclic nucleosides, HBV Bull. Chem. Soc. Ethiop. 2010, 24(3), 439-446.

Source: Bulletin of the Chemical Society of Ethiopia

DOI: 10.4314/bcse.v24i3.60692

Authors: Henry Yu, Tesfaye Serbessa

Institution: Elizabeth City State University

Language: English

Topic: HIV/AIDS drug development and treatment

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Utah State University, Georgetown University, National Institute of Allergy and Infectious Diseases