Work

Parathyroid hormone acutely increases polyphosphoinositides of the rabbit kidney cortex by a cycloheximide-sensitive process.

Year: 1980

Type: article

Abstract: Parathyroid hormone(PTH) rapidly increases the concentrations of diphosphoinositide and triphosphoinositide in rabbit kidney cortex. Cycloheximide pretreatment abolishes these effects of PTH. These findings are similar to those reported for adrenocorticotropin and cyclic AMP action in the adrenal cortex, and suggest a common mechanism. Cycloheximide-sensitive effects of PTH, e.g., phosphaturia, may require polyphosphoinositides and/or other phospholipids.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci109818

Authors: R V Farese, P Bidot-López, A Sabir, J S Smith, B Schinbeckler, R Larson

Institution: University of South Florida

Language: English

Topic: Parathyroid Disorders and Treatments

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2030140844

FWCI: 10.57

Cites: 26

Cited by: 60

Related to: 10