Work

Guided tours: from precursor snoRNA to functional snoRNP

Year: 1999

Type: article

Abstract: Small nucleolar RNAs (snoRNAs) use base pairing to guide modification of conserved nucleotides in functionally important regions of ribosomal RNA. The box C/D snoRNAs direct 2'-O-methylation and the box H/ACA snoRNAs direct pseudouridylation. Each snoRNA interacts with proteins, many of them newly identified. Progress in understanding how snoRNA sequences are stored within genomes, liberated from precursor molecules and targeted to the nucleolus has begun to elucidate each step in the biogenesis of these critical contributors to ribosome formation.

Source: Current Opinion in Cell Biology

DOI: 10.1016/s0955-0674(99)80053-2

Authors: Lara B Weinstein, Joan A Steitz

Institutions: Howard Hughes Medical Institute, Yale University

Language: English

Topic: RNA modifications and cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,390

Funder: National Institute of General Medical Sciences