Year: 2000
Type: article
Abstract: Src was initially discovered as the oncogenic protein (v-Src) of the retrovirus Rous sarcoma virus. A ubiquitously expressed and highly conserved cellular homolog of v-Src was subsequently discovered. Much of the original research on v-Src and its cellular homolog (Src) paved the way for our current understanding of how oncogenes cause cell transformation. The Src family of nonreceptor protein tyrosine kinases, including Src, Lyn, Fyn, Lck, Hck, Fgr, Blk, and Yes, have important roles in receptor signaling and cellular communication (reviewed in Thomas and Brugge 1997). While most Src kinases are broadly expressed (i.e., Src, Fyn, Yes), certain members of the family such as Hck, Blk, or Lck exhibit a restricted tissue expression.
Source: Cell
Author: Joseph Schlessinger
Institutions: NYU Langone Health, New York University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $11,400
OpenAlex ID: W2030413647