Work

Pharmacokinetics of Zidovudine Dosed Twice Daily According to World Health Organization Weight Bands in Ugandan HIV-infected Children

Year: 2013

Type: article

Abstract: Data on zidovudine pharmacokinetics in children dosed using World Health Organization weight bands are limited. About 45 HIV-infected, Ugandan children, 3.4 (2.6-6.2) years, had intensive pharmacokinetic sampling. Geometric mean zidovudine AUC0-12h was 3.0 h.mg/L, which is higher than previously observed in adults, and was independently higher in those receiving higher doses, younger and underweight children. Higher exposure was also marginally associated with lower hemoglobin.

Source: The Pediatric Infectious Disease Journal

DOI: 10.1097/inf.0000000000000143

Authors: Quirine Fillekes, Lindsay Kendall, Sabrina Kitaka, Peter Mugyenyi, Philippa Musoke, Milly Ndigendawani, Mutsa Bwakura-Dangarembizi, Diana M. Gibb, David Burger, Ann Sarah Walker

Institutions: Radboud University Nijmegen, University of Zimbabwe, Radboud University Medical Center, Joint Clinical Research Centre, MRC Clinical Trials Unit at UCL, Medical Research Council, Mulago Hospital

Language: English

Topic: HIV/AIDS drug development and treatment

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,971

Funders: Wellcome Trust, National Institute for Health and Care Research, Department for International Development, Medical Research Council

Awards: G29960001, Wellcome Trust Bloomsbury Centre for Global Health Research.

OpenAlex ID: W2030488466

FWCI: 0.484

Cites: 10

Cited by: 10

Related to: 10