Work

732. Avian Sarcoma Leukosis Virus Vectors Can Transduce Rhesus Macaque HSCs and Result in a Potentially Safer Integration Profile

Year: 2006

Type: article

Abstract: Retroviral-induced insertional mutagenesis has generated renewed concern due to the occurrence of three cases of T cell lymphoproliferative disease in the otherwise successful French SCID- X1 trial, as well as increasing anecdotal reports documenting oncogenesis after murine retroviral or lentiviral vector based gene transfer. Several genome-wide integration site analyses indicate MLV and HIV based vectors integrate preferentially into regions adjacent to or within human RefSeq genes, thus increasing the possibility of insertional mutagenesis.

Source: Molecular Therapy

DOI: 10.1016/j.ymthe.2006.08.813

Authors: Jingqiong Hu, Andrea Ferris, Allen Krause, Robert E. Donahue, Stephen H. Hughes, Cynthia E. Dunbar

Institutions: National Heart, Lung, and Blood Institute, National Institutes of Health, National Cancer Institute

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500