Work

Challenges of Designing Trials for the Primary Prevention of Stroke

Year: 2008

Type: article

Abstract: BACKGROUND AND PURPOSE: Prevention of a first stroke is an important strategy to reduce morbidity and mortality associated with cerebrovascular disease. In this discussion, we review challenges to development of clinical trials for prevention of a first stroke. Summary of Review- We discuss prevention of first stroke in the context of clinical trial design in the ARRIVE trial and a primary prevention trial in development for the elderly. CONCLUSIONS: Stroke is an important outcome in cerebrovascular disease trials in the elderly, but it may be trumped by coronary heart disease as a more common end point.

Source: Stroke

DOI: 10.1161/strokeaha.108.526947

Author: Philip B. Gorelick

Institutions: University of Illinois Chicago, Alexian Brothers Health System

Language: English

Topic: Acute Ischemic Stroke Management

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2030618594

FWCI: 1.478

Cites: 18

Cited by: 10

Related to: 10