Work

Developmental acquisition of basement membrane heterogeneity: type IV collagen in the avian lens capsule.

Year: 1983

Type: article

Abstract: To investigate potential heterogeneity and developmental changes in basement membranes during embryogenesis, we performed immunohistochemical analyses on lens capsules in chicken embryos of different ages using domain-specific monoclonal antibodies against type IV collagen. We found that the capsule of the newly formed lens stained uniformly with antibodies against this component of basement membranes, but with increasing age and differentiation of the lens cells the anterior lens capsule remained brightly fluorescent while staining of the posterior capsule became relatively much less intense. This antero-posterior gradient of anti-type IV collagen antibody reactivity demonstrated that developmentally-regulated changes can occur within a single, continuous basement membrane.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.97.3.940

Authors: J M Fitch, R Mayne, T F Linsenmayer

Institutions: University of Alabama, University of Alabama at Birmingham, Harvard University, Massachusetts General Hospital

Language: English

Topic: Cell Adhesion Molecules Research

Subfield: Immunology and Allergy

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

OpenAlex ID: W2030740044

FWCI: 1.231

Cites: 19

Cited by: 52

Related to: 10