Work

The high‐risk benign tumor: Evidence from the two‐stage skin cancer model and relevance for human cancer

Year: 2007

Type: article

Abstract: Benign tumors that form following chemical initiation and promotion in the mouse skin can be grouped into two classes. The majority of papillomas do not progress to squamous cell carcinoma (SCC), and these are designated as low-risk or terminally benign papillomas. In contrast, a much smaller group forms the true precursor to the SCC, and these have a significantly higher frequency and rate of malignant conversion than the bulk of low-risk papillomas. In standard two-stage carcinogenesis studies both tumor types are present, but grossly indistinguishable. Here we describe properties and potential origins of high-risk papillomas and discuss the relevance of this model for certain human cancers with defined premalignant states.

Source: Molecular Carcinogenesis

DOI: 10.1002/mc.20345

Authors: Adam Glick, Andrew Ryscavage, Rolando Perez‐Lorenzo, Henry Hennings, Stuart Yuspa, Nadine Darwiche

Institutions: Pennsylvania State University, National Institutes of Health, National Cancer Institute, American University of Beirut

Language: English

Topic: Nonmelanoma Skin Cancer Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze