Work

Oxidative Coupling of Enolates, Enol Silanes, and Enamines: Methods and Natural Product Synthesis

Year: 2012

Type: article

Abstract: The oxidative coupling of enolates, enol silanes, and enamines provides a direct method for the construction of useful 1,4-dicarbonyl synthons. Despite being first reported in 1935, with subsequent important advances beginning in the 1970's, the development of this powerful reaction into a reliable methodology was somewhat limited. In recent years, there have been a number of reports from several research groups demonstrating advances in several neglected areas of oxidative coupling. This microreview summarizes these new advances in methodology and provides an overview of recent natural product syntheses that showcase the power of these transformations.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.201200665

Authors: Fenghai Guo, Michael D. Clift, Regan J. Thomson

Institutions: Northwestern University, Princeton University

Language: English

Topic: Organic Chemistry Synthesis Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences

Award: New Methods for the Concise Synthesis of Bioactive Polycyclic Molecules