Work

Mycobacterium tuberculosisCDC1551 Is Resistant to Reactive Nitrogen and Oxygen Intermediates In Vitro

Year: 2002

Type: article

Abstract: Resistance to reactive oxygen intermediates and reactive nitrogen intermediates in vitro of a clinical isolate of Mycobacterium tuberculosis (CDC1551) that caused a large outbreak of tuberculosis was compared to that of M. tuberculosis strains CB3.3, H37Rv, H37Ra, Erdman, RJ2E, C.C. 13, and C.C. 22 as well as M. bovis strains Ravenel and BCG. CDC1551 and CB3.3 were significantly more resistant to both hydrogen peroxide (H(2)O(2)) and acidified sodium nitrite than were the other strains tested. This biological phenotype may serve as an in vitro marker for clinical strains of M. tuberculosis likely to cause a large outbreak of tuberculosis.

Source: Infection and Immunity

DOI: 10.1128/iai.70.7.3965-3968.2002

Authors: Marcia A. Firmani, Lee W. Riley

Institution: University of California, Berkeley

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, Centers for Disease Control and Prevention, National Heart, Lung, and Blood Institute, National Institute on Drug Abuse