Work

Structure and Properties of the Vacuolar (H+)-ATPases

Year: 1999

Type: review

Abstract: The vacuolar (H+)-ATPases (or V-ATPases) are a family of ATP-dependent proton pumps that are responsible for acidification of intracellular compartments in eukaryotic cells (1-3). Acidification of vacuolar compartments plays an important role in a variety of cellular processes, particularly membrane traffic processes. In receptor-mediated endocytosis, acidification of endosomes serves as a signal that activates release of internalized ligands (such as low density lipoprotein and insulin) from their receptors.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.274.19.12951

Author: Michael Forgac

Institution: Tufts University

Language: English

Topic: ATP Synthase and ATPases Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

Funder: National Institute of General Medical Sciences