Work

Acoustic response from adherent targeted contrast agents

Year: 2006

Type: article

Abstract: In ultrasonic molecular imaging, encapsulated micron-sized gas bubbles are tethered to a blood vessel wall by targeting ligands. A challenging problem is to detect the echoes from adherent microbubbles and distinguish them from echoes from nonadherent agents and tissue. Echoes from adherent contrast agents are observed to include a high amplitude at the fundamental frequency, and significantly different spectral shape compared with free agents (p <0.0003). Mechanisms for the observed acoustical difference and potential techniques to utilize these differences for molecular imaging are proposed.

Source: The Journal of the Acoustical Society of America

DOI: 10.1121/1.2364303

Authors: Shukui Zhao, Dustin E. Kruse, Katherine W. Ferrara, Paul A. Dayton

Institution: University of California, Davis

Language: English

Topic: Ultrasound and Hyperthermia Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering

Awards: Engineering approaches to molecular imaging, Ultrasound imaging and local drug delivery in tumors, TARGETED ULTRASOUND IMAGING OF TUMORS, High-Sensitivity Molecular Imaging with Ultrasound (RMI), Insonation of ultrasound microbubbles at low frequency to enhance image-guided therapy