Work

Jejunal lysozyme activity and the Paneth cell in coeliac disease.

Year: 1979

Type: article

Abstract: The jejunal mucosa of patients with coeliac disease contains significantly fewer Paneth cells (PCC) per crypt (p less than 0.001) and tissue lysozyme activity (JLA) P less than 0.001) when compared with a group of subjects with normal jejunal mucosa. Neither PCC nor JLA return to normal with complete clinical recovery and otherwise complete histological recovery on a gluten free diet. There is a significant linear correlation between JLA and PCC suggesting that the Paneth cell is the principal source of jejunal lysozyme.

Source: Gut

DOI: 10.1136/gut.20.1.55

Authors: M Ward, A Ferguson, M A Eastwood

Institutions: Royal Brisbane and Women's Hospital, Western General Hospital, University of Edinburgh

Language: English

Topic: Celiac Disease Research and Management

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2031236810