Work

The putative transforming protein of S13 avian erythroblastosis virus is a transmembrane glycoprotein with an associated protein kinase activity.

Year: 1985

Type: article

Abstract: S13 is an avian retrovirus that transforms both fibroblasts and erythroblasts. The gene product responsible for the oncogenic effects of S13 is the env-related glycoprotein gp155. In this report we show that gp155 is a transmembrane protein with a 55-kDa cytoplasmic domain. Pulse-chase analysis shows that gp155 was cleaved posttranslationally into two glycosylated proteins, gp85 and gp70. In addition, we show that a tyrosine protein kinase activity is associated only with the gp70 protein in microsomes and in immune complexes.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.82.23.8237

Authors: M J Hayman, G Kitchener, P K Vogt, H Beug

Institutions: University of Southern California, St Bartholomew's Hospital, European Molecular Biology Laboratory

Language: English

Topic: T-cell and Retrovirus Studies

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: green

Funder: National Cancer Institute

Awards: G1872121337, G4482193401