Work

An Unusual Gene Dosage Effect of p27kip1 in a Mouse Model of Prostate Cancer

Year: 2005

Type: article

Abstract: Expression of the p27kip1 cell cycle inhibitor is downregulated in a wide range of carcinomas, yet it is rarely inactivated completely. Our recent studies of a mouse model of prostate carcinogenesis have revealed that cancer progression is enhanced by a two-fold reduction in p27kip1 gene dosage, but is unexpectedly inhibited by further decrease in p27kip1 activity. This paradoxical finding may explain the unusual features of p27kip1 downregulation in human cancer, and also suggests a potential route for therapeutic intervention.

Source: Cell Cycle

DOI: 10.4161/cc.4.3.1530

Authors: Cory Abate-Shen, Michael M. Shen

Institution: Rutgers Cancer Institute

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: U.S. Department of Defense, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, DOD Prostate Cancer Research Program