Caffeinated and Alcoholic Beverage Intake in Relation to Ovulatory Disorder Infertility
Year: 2009
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Many studies have examined whether caffeine, alcohol, or specific beverages containing these substances affect fertility in women. However, most of these studies have retrospectively collected information on alcohol and caffeine intake, making the results susceptible to biases. METHODS: We followed 18,555 married women without a history of infertility for 8 years as they attempted to become (or became) pregnant. Diet was measured twice during this period and prospectively related to the incidence of ovulatory disorder infertility. RESULTS: There were 438 incident report of ovulatory disorder infertility during follow-up. Intakes of alcohol and caffeine were unrelated to the risk of ovulatory disorder infertility. Comparing the highest to lowest categories of intake, the multivariate-adjusted relative risk, was 1.11 (95% confidence interval = 0.76-1.64; P for trend 0.78) for alcohol and 0.86 (0.61-1.20; 0.44) for total caffeine. However, intake of caffeinated soft drinks was positively related to ovulatory disorder infertility. Comparing the highest to lowest categories of caffeinated soft drink consumption, the RR was 1.47 (1.09-1.98; 0.01). Similar associations were observed for noncaffeinated, sugared, diet, and total soft drinks. CONCLUSIONS: Our findings do not support the hypothesis that alcohol and caffeine impair ovulation to the point of decreasing fertility. The association between soft drinks and ovulatory disorder infertility seems not to be attributable to their caffeine or sugar content, and deserves further investigation.
Source: Epidemiology
Institutions: Brigham and Women's Hospital, Harvard University
Language: English
Topic: Coffee research and impacts
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: HYPERTENSIVE DISORDERS OF PREGNANCY, ANALGESIC USE AND THE RISK OF CHRONIC RENAL FAILURE, Cohort Study of Genetic Susceptibility to Breast Cancer, G2940603163, PREMENOPAUSAL HORMONE LEVELS AND RISK OF BREAST CANCER, G3428241583, G3602225402, CHRONIC LIFE STRESS AND INCIDENT ASTHMA IN ADULT WOMEN, G4666650047, G5362739798, G5551855518, RANDOMIZED TRIAL OF FOLATE AND COLORECTAL ADENOMA, G6425101868, G6548527268, Prospective Studies of Diet and Cancer in Men and Women, Risk Factors for Breast Cancer in Younger Nurses, G8005855904, Premenopausal Hormone Levels and Risk of Breast Cancer, G8821123181
OpenAlex ID: W2031339009