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Association of HIV viral load with monocyte chemoattractant protein-1 and atherosclerosis burden measured by magnetic resonance imaging

Year: 2009
Type: article
Study design: Observational Study
Abstract: BACKGROUND: HIV-infected individuals may be at increased risk for atherosclerosis. Although this is partially attributable to metabolic factors, HIV-associated inflammation may play a role. OBJECTIVE: To investigate associations of HIV disease with serum monocyte chemoattractant protein-1/chemokine (C-C motif) ligand 2 (MCP-1/CCL2) levels and atherosclerosis burden. DESIGN: A cross-sectional analysis. METHODS: : Serum MCP-1/CCL2, fasting lipids, and glucose tolerance were measured in 98 HIV-infected and 79 demographically similar uninfected adults. Eighty-four participants had MRI of the carotid arteries and thoracic aorta to measure atherosclerosis burden. Multivariate analyses were performed using linear regression. RESULTS: Mean MCP-1/CCL2 levels did not differ between HIV-infected and uninfected participants (P = 0.65). Among HIV-infected participants, after adjusting for age, BMI, and cigarette smoking, HIV-1 viral load was positively associated with MCP-1/CCL2 (P = 0.02). Multivariate analyses adjusting for sex, low-density lipoprotein cholesterol, total cholesterol:high-density lipoprotein cholesterol ratio, cigarette smoking, MCP-1/CCL2, and protease inhibitor use found that HIV infection was associated with greater mean thoracic aorta vessel wall area (VWA, P < 0.01) and vessel wall thickness (VWT, P = 0.03), but not with carotid artery parameters. Compared with being uninfected, having detectable HIV-1 viremia was associated with greater mean thoracic aorta VWA (P < 0.01) and VWT (P = 0.03), whereas being HIV-infected with undetectable viral load was associated with greater thoracic aorta VWA (P = 0.02) but not VWT (P = 0.15). There was an independent positive association of MCP-1/CCL2 with thoracic aorta VWA (P = 0.01) and VWT (P = 0.01). CONCLUSION: HIV-1 viral burden is associated with higher serum levels of MCP-1/CCL2 and with atherosclerosis burden, as assessed by thoracic aorta VWA and VWT.
Source: AIDS
DOI: 10.1097/qad.0b013e328329c76b
Authors: Michelle Floris-Moore, Zahi A Fayad, Joan W Berman, Venkatesh Mani, Ellie E Schoenbaum, Robert S Klein, Karen B Weinshelbaum, Valentin Fuster, Andrea A Howard, Yungtai Lo, Alison D Schecter
Institutions: University of North Carolina at Chapel Hill, Albert Einstein College of Medicine, Montefiore Medical Center, Yeshiva University, Icahn School of Medicine at Mount Sinai, ICAP Global Health, Columbia University
Language: English
Field: Medicine
Open Access status: green
Funders: American Heart Association, Yeshiva University, Albert Einstein College of Medicine, Yeshiva University, Center for AIDS Research, University of Washington, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute on Drug Abuse, National Institute of Allergy and Infectious Diseases, National Center for Research Resources
Awards: G1200040921, G1665807352, HIV, Chemokine Receptors, and Vascular Smooth Muscle, GENERAL CLINICAL RESEARCH CENTER M01 RR12248, G2914726324, Center for AIDS Research (CFAR), Artherosclerosis/bone loss/drug use/HIV in older men, NATURAL HISTORY OF MENOPAUSE IN HIV INFECTED DRUG USERS, Mechanisms of HAD:Role of CCL2 BBB & HIV Infection, Mechanisms of HIV Tat neurotoxicity and CCL2 protection, MR/PET Imaging of coronary atherosclerosis, G7371924645, Mentored Clinical Research Scholar Program
OpenAlex ID: W2031395625
FWCI: 3.026
Cites: 32
Cited by: 31
Related to: 10