Work

Characterization of skeletal phenotypes of TRα1PV and TRβPV mutant mice: implications for tissue thyroid status and T3 target gene expression

Year: 2006

Type: article

Abstract: Bone development is extremely sensitive to alterations in thyroid status. Recently, we analyzed the skeletal phenotypes of mice with the dominant negative resistance to thyroid hormone (RTH) mutation PV targeted to either the thyroid hormone receptor (TR) alpha1 or beta gene. This perspective summarizes our findings to date and explores the wider implications for thyroid status and T3 target gene expression in individual tissues.

Source: Nuclear Receptor Signaling

DOI: 10.1621/nrs.04011

Authors: Patrick J. O'Shea, J.H. Duncan Bassett, Sheue-yann Cheng, Graham R. Williams

Institutions: National Institutes of Health, National Cancer Institute, Imperial College London

Language: English

Topic: Thyroid Disorders and Treatments

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Medical Research Council