Work

189: γδ T cells as immunotherapy for glioblastoma multiforme

Year: 2007

Type: article

Abstract: Background: Despite advances in therapy, the survival for glioblastoma multiforme (GBM) has remained unchanged for 50 years. We have investigated a cellular therapeutic therapy based on innate immune recognition of GBM using ex vivo expanded γδ T cells that are highly cytotoxic to GBM lines. Unlike αβ+CD8+ cytotoxic T lymphocytes, γδ T cells act directly against stress-associated antigens expressed on GBM and do not require MHC antigen recognition.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2006.12.193

Authors: C. Suarez, N.L. Bryant, Y. Gillespie, R.D. Lopez, J.M. Markert, L.S. Lamb

Institution: University of Alabama at Birmingham

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Genetics (clinical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650