Work

SIN3B, the SASP, and pancreatic cancer

Year: 2014

Type: article

Abstract: Cellular senescence is classically considered a tumor suppressive mechanism. In addition to having stably exited the cell cycle, senescent cells secrete inflammatory factors. We recently demonstrated that senescence correlates with accelerated cancer progression in a mouse model of pancreatic ductal adenocarcinoma. Here, we discuss the implications of this study.

Source: Molecular & Cellular Oncology

DOI: 10.4161/23723548.2014.969167

Authors: David J Cantor, Gregory David

Institution: New York University

Language: English

Topic: Telomeres, Telomerase, and Senescence

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,590