Year: 1987
Type: article
Abstract: The occurrence of chronic lymphocytic leukaemia in this patient contemporaneous with his antibody positivity may be coincidental, but it also raised the possibility of various causal associations.There is evidence that other retroviruses that infect T cells can also integrate into and transform B cells in a clonal fashion.4Furthermore, B lymphoblastoid cell lines transformed by Epstein-Barr virus have been shown to be permissive to HIV infection.5Our use of the anti-HIV serum detected no viral antigens in the neoplastic B cells.Such evidence cannot, however, exclude the possibility of non-transcribed genomic integration of the virus in the cellular DNA.Such analysis will require the use of viral recombinant cDNA genotyping of the leukaemia B cells.We thank the Grampian Health Board for financial support, Dr Margaret Moffat, departnent ofbacteriology (virology), for viral antibody assays, and Miss Ann Mackay for typing the manuscript.
Source: BMJ
Institution: University of Aberdeen
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2031797728