Work

The IRF family of transcription factors

Year: 2012

Type: article

Abstract: Members of the interferon-regulatory factor (IRF) proteins family were originally identified as transcriptional regulators of the Type I interferon system. Thanks to consistent advances made in our understanding of the immunobiology of innate receptors, it is now clear that several IRFs are critical for the elicitation of innate pattern recognition receptors, and-as a consequence-for adaptive immunity. In addition, IRFs have attracted great attentions as they modulate cellular responses that are involved in tumorigenesis. The regulation of oncogenesis by IRFs has important implications for understanding the host susceptibility to several Types of cancers, their progression, as well as the potential for therapeutic interventions.

Source: OncoImmunology

DOI: 10.4161/onci.22475

Authors: Hideyuki Yanai, Hideo Negishi, Tadatsugu Taniguchi

Institutions: Japan Science and Technology Agency, Institute of Industrial Science, The University of Tokyo, The University of Tokyo

Language: English

Topic: interferon and immune responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913