Work

Ros‐mediated activation of NF‐κB and Foxo during muscle disuse

Year: 2009

Type: article

Abstract: We examined reactive oxygen species as upstream activators of nuclear factor kappaB; (NF-kappaB) and forkhead box O (Foxo) in skeletal muscle during disuse atrophy. Catalase, an enzyme that degrades H2O2, was overexpressed in soleus muscles via plasmid injection prior to 7 days of hindlimb immobilization. The increased catalase activity abolished immobilization-induced transactivation of both NF-kappaB and Foxo and attenuated the loss of muscle mass. Thus, H2O2 may be an important initiator of these signaling pathways that lead to muscle atrophy.

Source: Muscle & Nerve

DOI: 10.1002/mus.21526

Authors: Stephen L. Dodd, Brittany J. Gagnon, Sarah M. Senf, Brian A. Hain, Andrew R. Judge

Institution: University of Florida

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute on Aging, National Institute of Arthritis and Musculoskeletal and Skin Diseases