Work

Four pillars of the S-phase checkpoint

Year: 2013

Type: preprint

Abstract: The yeast Mec1 kinase is a key regulator of the DNA damage response (DDR). In this issue of Genes & Development, Kumar and Burgers (pp. 313-321) report that Ddc1, Dpb11, and Dna2 function in concert to activate Mec1 during S phase of the cell cycle. Furthermore, the Tel1 kinase also contributes to the DDR in S phase when Mec1 activation is compromised.

Source: Genes & Development

DOI: 10.1101/gad.213306.113

Author: Lee Zou

Institutions: Harvard University, Massachusetts General Hospital

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

Funders: Ellison Medical Foundation, National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences

Awards: G2552572490, G8416546321, G9000174243