Work

Novel Therapies Based on Mechanisms of HIV-1 Cell Entry

Year: 2003

Type: review

Abstract: Inhibitors of human immunodeficiency virus type 1 (HIV-1) enzymes are central to the treatment of HIV-1 infection, but the development of resistant viruses remains a problem. Another approach is to thwart the entry of the virus into cells by preventing the fusion of the viral envelope with the cell surface. This article reviews the way in which HIV-1 enters cells and potential means of denying the virus admission to cells.

Source: New England Journal of Medicine

DOI: 10.1056/nejmra022812

Authors: J. Michael Kilby, Joseph J. Eron

Institutions: University of Alabama at Birmingham, University of North Carolina at Chapel Hill

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of Allergy and Infectious Diseases, National Center for Research Resources