Work

Cell colonization in degradable 3D porous matrices

Year: 2008

Type: review

Abstract: Cell colonization is an important in a wide variety of biological processes and applications including vascularization, wound healing, tissue engineering, stem cell differentiation and biosensors. During colonization porous 3D structures are used to support and guide the ingrowth of cells into the matrix. In this review, we summarize our understanding of various factors affecting cell colonization in three-dimensional environment. The structural, biological and degradation properties of the matrix all play key roles during colonization. Further, specific scaffold properties such as porosity, pore size, fiber thickness, topography and scaffold stiffness as well as important cell material interactions such as cell adhesion and mechanotransduction also influence colonization.

Source: Cell Adhesion & Migration

DOI: 10.4161/cam.2.1.5884

Authors: Benjamin J. Lawrence, Sundararajan V. Madihally

Institution: Oklahoma State University

Language: English

Topic: Tissue Engineering and Regenerative Medicine

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

Open Access status: gold

Estimated APC paid: $2,306

Funders: Oklahoma Center for the Advancement of Science and Technology, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases