Work

Expedient Synthesis of Norbenzomorphan Library via Multicomponent Assembly Process Coupled with Ring-Closing Reactions

Year: 2012

Type: article

Abstract: A 124-member norbenzomorphan library has been prepared utilizing a novel multicomponent assembly process (MCAP) followed by a variety of ring-closing reactions to generate norbenzomorphan scaffolds that were readily derivatized via a series of aryl halide cross-coupling and nitrogen functionalization reactions. Biological screening has revealed some novel activities that have not been previously associated with this class of compounds.

Source: ACS Combinatorial Science

DOI: 10.1021/co300068a

Authors: James J. Sahn, Stephen F. Martin

Institution: The University of Texas at Austin

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences

Awards: G150393960, G1649042011, Generating Diverse Pilot-Scale Libraries for Screening, Synthesis of Nitrogen Containing Natural Products