Molecular Diversity and Regulation of Renal Potassium Channels
Year: 2004
Type: review
Abstract: K(+) channels are widely distributed in both plant and animal cells where they serve many distinct functions. K(+) channels set the membrane potential, generate electrical signals in excitable cells, and regulate cell volume and cell movement. In renal tubule epithelial cells, K(+) channels are not only involved in basic functions such as the generation of the cell-negative potential and the control of cell volume, but also play a uniquely important role in K(+) secretion. Moreover, K(+) channels participate in the regulation of vascular tone in the glomerular circulation, and they are involved in the mechanisms mediating tubuloglomerular feedback. Significant progress has been made in defining the properties of renal K(+) channels, including their location within tubule cells, their biophysical properties, regulation, and molecular structure. Such progress has been made possible by the application of single-channel analysis and the successful cloning of K(+) channels of renal origin.
Source: Physiological Reviews
Institution: Yale University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: G1311958902, G1400571731, Regulation of Glucose Homeostasis by the Kv1.3 Channel, HORMONAL REGULATION OF BLOOD PRESSURE, G2191624845, G2386108838, G2482593692, Cellular and Molecular Studies of Renal Transport, Role of Kir4.1 in Regulating NCC and ROMK in DCT, ROMK CHANNEL FUNCTION AND REGULATION IN KIDNEY, Modulation of K channels in renal collecting duct, Role of Kir4.1 in Regulating NCC and ROMK in DCT, Structure, Function and Regulation of Renal K Channels, Structure and Function of ROMK Channel in Kidney, G8206457460, G835600281, G8387399268, G8433263459
OpenAlex ID: W2032063322