Growth-inhibitory effect of hexa-N-acetylchitohexaose and chitohexaose against Meth-A solid tumor.
Year: 1988
Type: article
Abstract: Two oligosaccharides, hexa-N-acetylchitohexaose (NACOS-6) and chitohexaose (COS-6), consisting solely of N-acetyl-D-glucosamine and D-glucosamine, respectively, were found to be growth-inhibitory against Meth-A solid tumor transplanted into BALB/c mice, when each oligosaccharide was administered i.v. at a dose of more than 1 mg/kg. Mouse peritoneal macrophages elicited with casein underwent activation with these oligosaccharides in vitro to produce interleukin 1. Spleen cells from mice given these oligosaccharides also underwent acceleration of interleukin 2 production and cytolytic T-lymphocyte differentiation. Thus, the antitumor mechanism of NACOS-6 and COS-6 was assumed to involve increased production of lymphokines including interleukins 1 and 2, sequentially, leading to the manifesation of antitumor effect through proliferation of cytolytic T-lymphocytes.
DOI: 10.1248/cpb.36.784
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2032087142