Year: 1962
Type: article
Abstract: Kelly (1961) has shown that the intravenous administration of oestrogen does not affect spontaneous uterine motility.It is likely that it is the concentration of active oestrogen in the uterine muscle which matters.In this event the only effective route of administration may be into the utero-placental space or into the amniotic cavity.The possibility of intra-amniotic injection is foreshadowed by the work of Diczfalusy et al. (1961) on the metabolism of intra-amniotic oestrogens, and we propose to extend our trials using this route.Summary A controlled trial was done on the effect of oral oestriol or stilboestrol in women who were to be subjected to artificial rupture of the membranes for surgical induction of labour.It was found that these oestrogens had no demonstrable effect on the induction- delivery interval or on the length of labour.We are grateful to our statistical colleagues Mr. W. Z Billewicz and Miss R. Holliday for their help in the design of the trial and in dispensing tablets.Our thanks are due to the nursing staff at the Maternity Hospital for their co-operation, and to Dr. C. L. Hewett, of the Organon Laboratories, for the gift of oestrogen and dummy tablets.
Source: BMJ
Author: P. Hall
Institution: University of Sheffield
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2032204722