Biomarkers of Traumatic Injury Are Transported from Brain to Blood via the Glymphatic System
Year: 2015
Type: article
Abstract: The nonspecific and variable presentation of traumatic brain injury (TBI) has motivated an intense search for blood-based biomarkers that can objectively predict the severity of injury. However, it is not known how cytosolic proteins released from traumatized brain tissue reach the peripheral blood. Here we show in a murine TBI model that CSF movement through the recently characterized glymphatic pathway transports biomarkers to blood via the cervical lymphatics. Clinically relevant manipulation of glymphatic activity, including sleep deprivation and cisternotomy, suppressed or eliminated TBI-induced increases in serum S100β, GFAP, and neuron specific enolase. We conclude that routine TBI patient management may limit the clinical utility of blood-based biomarkers because their brain-to-blood transport depends on glymphatic activity.
Source: Journal of Neuroscience
Institutions: University of Rochester Medicine, University of Rochester
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: The glymphatic system, a new concept in glia biology, Failure of metabolite clearance in a model of multi-lacunar infarcts, ATP as the instigator of inflammatory responses to spinal cord injury, Alexander disease: mechanisms, modifiers, and therapeutics, Glymphatic function in a transgenic rat model of Alzheimer's disease
OpenAlex ID: W2032220418