Work

Life and Death of Lymphocytes: A Volume Regulation Affair

Year: 2011

Type: article

Abstract: The loss of cell volume, termed apoptotic volume decrease (AVD) has been a hallmark feature of apoptosis. However the role of this characteristic attribute of programmed cell death has always been questioned as to whether it plays an active or passive factor during apoptosis. Here we review studies that suggest that AVD plays an active role during apoptosis and the underlying flux of ions that results in this morphological event regulates the programmed cell death process.

Source: Cellular Physiology and Biochemistry

DOI: 10.1159/000335864

Authors: Carl D. Bortner, John A. Cidlowski

Institutions: National Institutes of Health, National Institute of Environmental Health Sciences

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institutes of Health