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The Role of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins in Virus Infection

Year: 1995

Type: review

Abstract: Enveloped viruses enter cells by a two-step process. The first step involves the binding of a viral surface protein to receptors on the plasma membrane of the host cell. After receptor binding, a membrane fusion reaction takes place between the lipid bilayer of the viral envelope and host cell membranes. This fusion reaction can occur either at the plasma membrane or in acidic endosomes following receptor-mediated endocytosis. In either case, the membrane fusion reaction delivers the viral nucleocapsid into the host cytoplasm, allowing the infection to proceed.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.270.41.23883

Authors: Eric O. Freed, Malcolm A. Martin

Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430