Work

Immunomodulatory properties of carbon nanotubes are able to compensate immune function dysregulation caused by microgravity conditions

Year: 2014

Type: article

Abstract: Spaceflights lead to dysregulation of the immune cell functionality affecting the expression of activation markers and cytokine production. Short oxidized multi-walled carbon nanotubes functionalized by 1,3-dipolar cycloaddition have been reported to activate immune cells. In this Communication we have performed surface marker assays and multiplex ELISA on primary monocytes and T cells under microgravity. We have discovered that carbon nanotubes, through their immunostimulatory properties, are able to fight spaceflight immune system dysregulations.

Source: Nanoscale

DOI: 10.1039/c4nr02711f

Authors: Claudia Crescio, Marco Orecchioni, Cécilia Ménard-Moyon, Francesco Sgarrella, Proto Pippia, Roberto Manetti, Alberto Bianco, Lucia Gemma Delogu

Institutions: University of Sassari, Centre National de la Recherche Scientifique, Institut de Biologie Moléculaire et Cellulaire

Language: English

Topic: Spaceflight effects on biology

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2032465261

FWCI: 2.348

Cites: 24

Cited by: 20

Related to: 10