Phosphatidylserine externalization and membrane blebbing are involved in the nonclassical export of FGF1
Year: 2011
Type: article
Abstract: The mechanisms of nonclassical export of signal peptide-less proteins remain insufficiently understood. Here, we demonstrate that stress-induced unconventional export of FGF1, a potent and ubiquitously expressed mitogenic and proangiogenic protein, is associated with and dependent on the formation of membrane blebs and localized cell surface exposure of phosphatidylserine (PS). In addition, we found that the differentiation of promonocytic cells results in massive FGF1 release, which also correlates with membrane blebbing and exposure of PS. These findings indicate that the externalization of acidic phospholipids could be used as a pharmacological target to regulate the availability of FGF1 in the organism.
Source: Journal of Cellular Biochemistry
DOI: 10.1002/jcb.23425
Institutions: Maine Medical Center Research Institute, Maine Medical Center, Maine Medical Center, Harold C. Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, University of Rochester Medicine, University of Rochester, University of Florence, University of Arkansas at Fayetteville
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: G4898174075, NUCLEAR PL SCRAMBLASE IN DIFFERENTIATION & APOPTOSIS, Phase III COBRE in Vascular Biology, COBRE in Stem Cell Biology and Regenerative Medicine, Release of FGF1 and Pathology of Angiogenesis, G800398904, COBRE in Vascular Biology, COBRE in Stem Cell Biology and Regenerative Medicine, PLSCR1 IN LEUKOCYTE PRODUCTION, MATURATION, & FUNCTION
OpenAlex ID: W2032520075