Year: 2010
Type: article
Abstract: In the present communication we report the fabrication a unique core-shell inorganic nanomaterial with potential therapeutic and diagnostic functions. It contains an iron-cobalt (FeCo) core that demonstrates MRI contrast property and a thin nanoshell of gold that inhibits the function of a pro-angiogenic growth factor, VEGF165. Au(FeCo) core-shell nanomaterials are fabricated in the gas phase and characterized using transmission electron microscopy (TEM), energy dispersive spectrum (EDS), inductively coupled plasma analysis (ICP) and magnetic resonance imaging (MRI). Inhibition of VEGF165 function by Au(FeCo) is demonstrated against VEGF165/VPF induced signaling cascades and proliferation of HUVECs. Self-contrast property of Au(FeCo) is determined in vitro by MRI after incubating HUVECs with Au(FeCo), demonstrating intrinsic contrast property of this potentially therapeutic nanomaterial. In brief, we report here the successful fabrication of an inorganic core-shell nanomaterials with potential therapeutic and diagnostic functions. It inhibits the function of VEGF165 and function as a MRI contrast agent.
Source: Cancer Nanotechnology
Institutions: Mayo Clinic, University of Minnesota
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,990
OpenAlex ID: W2032561701